Effects of Acute Mild and Moderate Hypoxia on Human Mood State

Space Med Med Eng (Beijing). 2000 Feb;13(1):1-5.


Objective: To explore the effects of acute mild and moderate hypoxia on human mood state.

Method: The mood states of 18 healthy male volunteers were evaluated by self-assessment questionnaires, profile of mood state (POMS) and state anxiety inventory (S-AI) after random exposure to simulated altitude of 300 m (control), 2800 m, 3600 m and 4400 m for 1 h in a hypobaric chamber.

Result: The data at 300 m level were taken as the baseline control. The negative mood state factor points (tension, fatigue etc.) increased gradually as the altitude level increased while V (vigor-activity) points had a tendency to decrease (P<0.05 or P<0.01). No significant difference was found in the points of (D, A) even under exposure to 4400 m (P>0.05). At the early period of 2800 m exposure the tension points of POMS and S-AI scores were higher than those of control level (P<0.05) then dropped to baseline level when exposure to this altitude for 1 h.

Conclusion: Exposure to acute mild hypobaric hypoxia at 2800 m for 1 h has adverse effect on mood state of healthy person and the negative effect was further aggravated with the increment of altitude level.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Aerospace Medicine*
  • Affect*
  • Altitude*
  • Anxiety*
  • Atmosphere Exposure Chambers
  • Atmospheric Pressure
  • Aviation
  • China
  • Humans
  • Hypoxia / psychology*
  • Male
  • Military Personnel / psychology
  • Psychological Tests
  • Surveys and Questionnaires