Design and synthesis of isoindoloquinoline derivatives as potential antitumor agents

Arch Pharm Res. 2002 Aug;25(4):416-20. doi: 10.1007/BF02976593.

Abstract

A series of isoindoloquinoline derivatives was synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines (HCT15, SK-OV-3, MDA-MB-468 and T-47D).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Base Pairing / drug effects
  • Chemical Phenomena
  • Chemistry, Physical
  • DNA / drug effects
  • Drug Design
  • Drug Screening Assays, Antitumor
  • Humans
  • Indicators and Reagents
  • Indoles / chemical synthesis*
  • Indoles / pharmacology*
  • Intercalating Agents / chemical synthesis*
  • Intercalating Agents / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Quinolines / chemical synthesis*
  • Quinolines / pharmacology*
  • Spectrophotometry, Infrared
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Indicators and Reagents
  • Indoles
  • Intercalating Agents
  • Quinolines
  • DNA