Mast cells: a cellular link between autoantibodies and inflammatory arthritis

Science. 2002 Sep 6;297(5587):1689-92. doi: 10.1126/science.1073176.


Previous studies have revealed that autoantibodies, complement components, and Fc receptors each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not known which cellular populations are responsive to these inflammatory signals. We find that two strains of mice deficient in mast cells, W/Wv and Sl/Sld, were resistant to development of joint inflammation and that susceptibility was restored in the W/Wv strain by mast cell engraftment. Thus, mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Arthritis / immunology*
  • Arthritis / pathology
  • Autoantibodies / immunology*
  • Blood Transfusion
  • Bone Marrow Transplantation
  • Cell Degranulation
  • Joints / immunology*
  • Joints / pathology
  • Male
  • Mast Cells / immunology*
  • Mast Cells / transplantation
  • Mice
  • Mice, Inbred C57BL


  • Autoantibodies