Refinement of wingless expression by a wingless- and notch-responsive homeodomain protein, defective proventriculus

Dev Biol. 2002 Sep 1;249(1):44-56. doi: 10.1006/dbio.2002.0746.

Abstract

Pattern formation during animal development is often induced by extracellular signaling molecules, known as morphogens, which are secreted from localized sources. During wing development in Drosophila, Wingless (Wg) is activated by Notch signaling along the dorsal-ventral boundary of the wing imaginal disc and acts as a morphogen to organize gene expression and cell growth. Expression of wg is restricted to a narrow stripe by Wg itself, repressing its own expression in adjacent cells. This refinement of wg expression is essential for specification of the wing margin. Here, we show that a homeodomain protein, Defective proventriculus (Dve), mediates the refinement of wg expression in both the wing disc and embryonic proventriculus, where dve expression requires Wg signaling. Our results provide evidence for a feedback mechanism that establishes the wg-expressing domain through the action of a Wg-induced gene product.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Patterning / physiology
  • Digestive System / embryology*
  • Digestive System / metabolism
  • Drosophila / embryology
  • Drosophila / genetics*
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Embryo, Nonmammalian
  • Gene Expression Regulation, Developmental
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / metabolism
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Mosaicism
  • Mutation
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism*
  • Receptors, Notch
  • Signal Transduction
  • Wings, Animal / embryology
  • Wings, Animal / metabolism
  • Wnt1 Protein

Substances

  • Drosophila Proteins
  • Homeodomain Proteins
  • Membrane Proteins
  • N protein, Drosophila
  • Proto-Oncogene Proteins
  • Receptors, Notch
  • Wnt1 Protein
  • dve protein, Drosophila
  • wg protein, Drosophila