Efficient liquid-phase synthesis of 2'-hydroxychalcones

Bioorg Med Chem Lett. 2002 Oct 7;12(19):2685-7. doi: 10.1016/s0960-894x(02)00553-x.

Abstract

The condensation of 2'-hydroxyacetophenone (1) with aromatic aldehydes (2) in a well closed vessel using microwave irradiation or classical heating at 132 degrees C, provides a fast and simple method for the liquid-phase synthesis of 2'-hydroxychalcones without formation of by-products. Antiproliferative activity of these compounds were evaluated using MCF-7 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Chalcone / analogs & derivatives*
  • Chalcone / chemical synthesis*
  • Chalcone / pharmacology*
  • Chalcones
  • Drug Screening Assays, Antitumor
  • Hot Temperature
  • Indicators and Reagents
  • Microwaves
  • Tumor Cells, Cultured

Substances

  • Aldehydes
  • Antineoplastic Agents
  • Chalcones
  • Indicators and Reagents
  • Chalcone
  • 2'-hydroxychalcone