Abstract
A group of isomers possessing a 2-, 3-, or 4-acetoxy moiety on the 3-phenyl substituent of rofecoxib were synthesized that exhibit highly potent, and selective, COX-2 inhibitory activity that have the potential to acetylate the COX-2 isozyme.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylation
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Aspirin / chemistry
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Aspirin / pharmacology
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Cyclooxygenase 1
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / chemical synthesis*
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Cyclooxygenase Inhibitors / chemistry*
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Humans
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Isoenzymes / genetics
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Isoenzymes / metabolism*
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Isomerism
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Lactones / chemistry*
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Membrane Proteins
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Models, Molecular
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Prostaglandin-Endoperoxide Synthases / genetics
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Prostaglandin-Endoperoxide Synthases / metabolism*
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Sulfones
Substances
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Isoenzymes
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Lactones
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Membrane Proteins
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Sulfones
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rofecoxib
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Cyclooxygenase 1
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Cyclooxygenase 2
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PTGS1 protein, human
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PTGS2 protein, human
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Prostaglandin-Endoperoxide Synthases
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Aspirin