Dendritic cells and the complexity of microbial infection

Trends Microbiol. 2002 Sep;10(9):425-61. doi: 10.1016/s0966-842x(02)02425-3.


Dendritic cells (DCs) can discriminate between different classes of microorganisms, present antigens to T cells and initiate innate and adaptive immune responses. DCs do not act individually, and their function can be fine-tuned by environmental and tissue factors as well as by the microorganisms themselves. Recent studies have reported DCs can integrate stimuli derived from microbial pathogens and other cells present at, or recruited to, the site of infection. These interactions can determine the success or failure of the immune response induced against pathogens.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology
  • Dendritic Cells / immunology*
  • Dendritic Cells / microbiology
  • Dendritic Cells / virology
  • Humans