A universal role for MyD88 in TLR/IL-1R-mediated signaling

Trends Biochem Sci. 2002 Sep;27(9):474-82. doi: 10.1016/s0968-0004(02)02145-x.


The MyD88 adapter protein links members of the toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily to the downstream activation of nuclear factor-kappaB and mitogen-activated protein kinases. Although originally identified as a myeloid-differentiation marker, MyD88 is now known to play an essential role in the innate immune response of insects and mammals. The generation of MyD88-deficient mice, as well as the identification of MyD88-related proteins and regulators of MyD88 signaling, has revealed new and important insights into the function of MyD88.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Animals
  • Antigens, Differentiation / genetics
  • Antigens, Differentiation / immunology
  • Antigens, Differentiation / physiology*
  • Bacterial Outer Membrane Proteins / immunology
  • Bacterial Outer Membrane Proteins / physiology*
  • Humans
  • Molecular Sequence Data
  • Myeloid Differentiation Factor 88
  • Receptors, Immunologic / antagonists & inhibitors
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / immunology
  • Receptors, Immunologic / physiology*
  • Receptors, Interleukin-1 / metabolism
  • Receptors, Interleukin-1 / physiology*
  • Sequence Homology, Amino Acid
  • Signal Transduction


  • Adaptor Proteins, Signal Transducing
  • Antigens, Differentiation
  • Bacterial Outer Membrane Proteins
  • MYD88 protein, human
  • Myeloid Differentiation Factor 88
  • Receptors, Immunologic
  • Receptors, Interleukin-1
  • TLR protein, bacteria