PeCoP: automatic determination of persistently conserved positions in protein families

Bioinformatics. 2002 Sep;18(9):1276-7. doi: 10.1093/bioinformatics/18.9.1276.


PeCoP is a WWW-based service which accepts a protein sequence, and reports positions that are conserved in close and distant sequence family members. The collation of family members is performed using iterative PSI-BLAST runs. Examining positional conservation in close and distant family members enables a better selection of positions that may play a role in determining the protein's structure and function.



Supplementary information:

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Conserved Sequence / genetics*
  • Databases, Protein*
  • Internet
  • Molecular Sequence Data
  • Proteins / classification*
  • Proteins / genetics*
  • Sequence Alignment / methods*
  • Sequence Analysis, Protein / methods
  • Software*


  • Proteins