The incidence of lymphoma in the UK haemophilia population between 1978 and 1999

AIDS. 2002 Sep 6;16(13):1803-7. doi: 10.1097/00002030-200209060-00014.

Abstract

Objective: To determine the incidence of non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD) in the UK haemophilia population during the 22 year period 1978-1999.

Design and methods: An analysis of patient data included on the UK Haemophilia Centre Doctors' Organisation lymphoma register. The number of cases of NHL and HD occurring in HIV-positive and negative patients in each 3-year period were compared with the expected incidence in the general male population.

Results: Eighty-nine cases of lymphoma were identified. Seventy-two cases (81%) occurred in HIV-positive patients (67 NHL, five HD), and 17 cases (19%) in HIV-negative patients (nine NHL, eight HD). The incidence of NHL in the HIV-positive cohort was significantly increased, with a ratio of observed to expected cases of 83.92 (P < 0.001) in the period 1985-1996. The ratio reduced to 42.15 during the period 1997-1999, presumably as a consequence of the introduction of highly active antiretroviral therapy (HAART). There was a significant excess of HD in HIV-positive patients, with an observed to expected ratio of 10.50 between 1985 and 1999 (based on five cases, P < 0.001). During the whole observation period, there was a significant excess of HD in HIV-negative patients, with an observed to expected ratio of 2.66 (based on eight cases, P < 0.05).

Conclusion: The incidence of lymphoma is significantly higher in HIV-positive UK haemophilia patients compared with HIV-negative individuals. Since the introduction of HAART, the incidence of lymphoma has tended to fall in the HIV-positive group.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • HIV Infections / complications*
  • Hemophilia A / complications*
  • Hodgkin Disease / epidemiology*
  • Humans
  • Incidence
  • Lymphoma, Non-Hodgkin / epidemiology*
  • Male
  • Registries
  • United Kingdom / epidemiology