Haemodialysis for the Prevention of Contrast-Induced Nephropathy: Outcome of 31 Patients With Severely Impaired Renal Function, Comparison With Patients at Similar Risk and Review

Invest Radiol. 2002 Sep;37(9):471-81. doi: 10.1097/01.RLI.0000023572.58117.55.

Abstract

Rationale and objectives: To investigate whether haemodialysis prevents contrast-induced nephropathy (definition: increase of serum-creatinine of >or= 0.5 mg/dL within 7 days).

Materials and methods: Thirty-one patients (mean serum-creatinine 4.01 +/- 1.83 mg/dL) were dialyzed for 4.36 +/- 1.0 hours within one hour after 278.4 +/- 160.5 mL of contrast medium.

Results: Dialysis resulted in a significant reduction of serum-creatinine (2.25 +/- 1.46 mg/dL; P< 0.0001) and stable mean serum-creatinine levels 2, 3, 4, and 7 days after contrast medium and at discharge compared with baseline values. However, 19 patients (61%) developed contrast-induced nephropathy within 7 days. Four patients had to be repeatedly dialyzed. A comparison of our patients' 48 hours-incidence of contrast-induced nephropathy (9/31; 29%) versus patients at comparable risk included in seven previous studies demonstrated a prophylactic effect of dialysis only versus a subgroup in one study.

Conclusions: Data provide no hint that haemodialysis prevents contrast-induced nephropathy. Therefore, postprocedural dialysis should be restricted to patients participating in clinical studies.

Publication types

  • Comparative Study

MeSH terms

  • Acute Kidney Injury / blood
  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / prevention & control*
  • Adult
  • Aged
  • Contrast Media / adverse effects*
  • Creatinine / blood
  • Humans
  • Kidney Function Tests
  • Middle Aged
  • Prospective Studies
  • Renal Dialysis*
  • Time Factors
  • Treatment Outcome

Substances

  • Contrast Media
  • Creatinine