Repeated sucrose access influences dopamine D2 receptor density in the striatum

Neuroreport. 2002 Aug 27;13(12):1575-8. doi: 10.1097/00001756-200208270-00017.


A decrease in D2 dopamine receptor subtype (D2R) binding in the striatum has been reported in obese individuals and drug addicts. We examined D2R density in the striatum of food-restricted rats that had contingent access to food with different incentive values. Results showed that animals receiving limited access to 0.3 M sucrose paired 2 h with a chow meal for 7 days had a significantly lower D2R binding in nucleus accumbens shell and dorsolateral striatum compared with animals that had limited access to chow. There was no differential binding, however, in the accumbens core in any of the groups. These findings indicate that feeding conditions and sucrose intake influence D2R density specifically in subregions of the striatum.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Autoradiography
  • Corpus Striatum / metabolism*
  • Dopamine / physiology
  • Feeding Behavior / physiology
  • Homeostasis / physiology
  • Male
  • Nucleus Accumbens / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D2 / metabolism*
  • Sucrose / pharmacology*


  • Receptors, Dopamine D2
  • Sucrose
  • Dopamine