Regulation of cytokine signaling and inflammation

Cytokine Growth Factor Rev. Aug-Oct 2002;13(4-5):413-21. doi: 10.1016/s1359-6101(02)00026-6.

Abstract

Inflammation progresses by the action of pro-inflammatory cytokines, including interleukin-1 (IL-1), the tumor necrosis factor (TNF), gamma-interferon (IFNgamma), IL-12, IL-18, and the granulocyte-macrophage colony-stimulating factor, and is resolved by anti-inflammatory cytokines such as IL-4, IL-10, IL-13, IFNalpha, and the transforming growth factor (TGF)beta. The intracellular signal transduction pathways of these cytokines have been studied extensively, and these pathways ultimately activate transcription factors, such as NF-kappaB, Smad, and STATs. Recently, the negative-feedback regulation of these pathways has been identified. In this review, we provide examples of the relationship between cytokine signal transduction, negative-signal regulation, and inflammatory disease models. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytokines / physiology*
  • DNA-Binding Proteins / physiology
  • Feedback, Physiological
  • Gene Expression Regulation / physiology
  • Growth Substances / physiology
  • Humans
  • I-kappa B Proteins / physiology
  • Inflammation / genetics
  • Inflammation / physiopathology*
  • Inflammatory Bowel Diseases / physiopathology
  • Mice
  • Mice, Knockout
  • Multigene Family
  • NF-kappa B / physiology
  • Phosphorylation
  • Protein Kinases / physiology
  • Protein Processing, Post-Translational / physiology
  • Receptors, Cytokine / physiology
  • Repressor Proteins / genetics
  • Repressor Proteins / physiology
  • Signal Transduction / physiology*
  • Smad Proteins
  • Trans-Activators / physiology
  • Transcription Factors / physiology
  • Transcription, Genetic

Substances

  • Cytokines
  • DNA-Binding Proteins
  • Growth Substances
  • I-kappa B Proteins
  • NF-kappa B
  • Receptors, Cytokine
  • Repressor Proteins
  • Smad Proteins
  • Trans-Activators
  • Transcription Factors
  • Protein Kinases