Amplitude-integrated encephalography in pyridoxine-dependent seizures and pyridoxine-responsive seizures

Acta Paediatr. 2002;91(8):977-80. doi: 10.1080/080352502760148748.


Pyridoxine-dependent seizures are rare in newborn infants, although recent data suggest that the prevalence probably is underestimated. In all newborn infants with recurrent epileptic seizures the general recommendation is to administer pyridoxine and simultaneously record an electroencephalogram (EEG).

Conclusion: One infant with pyridoxine-responsive seizures and another with pyridoxine-dependent seizures had different electroclinical responses on amplitude-integrated EEG monitoring (aEEG) when pyridoxine was administered.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / drug effects*
  • Brain / physiopathology*
  • Electroencephalography
  • Epilepsy / chemically induced*
  • Epilepsy / drug therapy*
  • Epilepsy / physiopathology
  • Humans
  • Infant, Newborn
  • Male
  • Pyridoxine / adverse effects*
  • Pyridoxine / therapeutic use*


  • Pyridoxine