RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

Cell Mol Life Sci. 2002 Jul;59(7):1117-28. doi: 10.1007/s00018-002-8491-x.


Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes of ligands, including advance glycation end-products, amyloid beta peptide and the family of beta sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alzheimer Disease / etiology
  • Amyloidosis / etiology
  • Animals
  • Arteriosclerosis / etiology
  • Arteriosclerosis / metabolism
  • Arteriosclerosis / pathology
  • Cell Movement
  • Chronic Disease
  • Diabetic Angiopathies / etiology
  • Diabetic Angiopathies / metabolism
  • Diabetic Angiopathies / pathology
  • Homeostasis
  • Humans
  • Immunoglobulins / classification
  • Inflammation / etiology
  • Mice
  • Neoplasms / etiology
  • Neoplasms / pathology
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic / metabolism
  • Receptors, Immunologic / physiology*
  • Signal Transduction


  • Immunoglobulins
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic