Orphan nuclear receptors in T lymphocyte development

J Leukoc Biol. 2002 Sep;72(3):440-6.

Abstract

Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lymphocyte development. The orphan nuclear receptor RORgamma has been shown to promote thymocyte survival by activating the expression of antiapoptotic protein Bcl-x(L). RORgamma is also required for the development of lymph nodes and Peyer's patches. The orphan receptors Nur77 and Nor1 are involved in TCR-mediated cell death and thymocyte-negative selection. These studies provide novel insights into the molecular mechanisms of T lymphocyte development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Survival
  • Clonal Deletion
  • Cytotoxicity, Immunologic
  • DNA-Binding Proteins / physiology*
  • Gene Expression Regulation
  • Hematopoiesis / physiology*
  • Humans
  • Immunity, Cellular
  • Lymph Nodes / cytology
  • Lymph Nodes / growth & development
  • Mice
  • Mice, Knockout
  • Mice, Neurologic Mutants
  • Multigene Family
  • Nerve Tissue Proteins*
  • Nuclear Proteins / physiology*
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • Nuclear Receptor Subfamily 4, Group A, Member 1
  • PC12 Cells
  • Peyer's Patches / cytology
  • Peyer's Patches / growth & development
  • Protein Isoforms / physiology
  • Proto-Oncogene Proteins c-bcl-2 / biosynthesis
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Rats
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Receptors, Retinoic Acid*
  • Receptors, Steroid
  • Receptors, Thyroid Hormone*
  • T-Lymphocytes / cytology*
  • T-Lymphocytes / metabolism
  • Thymus Gland / cytology
  • Transcription Factors / physiology*
  • bcl-X Protein

Substances

  • BCL2L1 protein, human
  • Bcl2l1 protein, mouse
  • Bcl2l1 protein, rat
  • DNA-Binding Proteins
  • NR4A1 protein, human
  • NR4A3 protein, human
  • Nerve Tissue Proteins
  • Nr4a1 protein, mouse
  • Nr4a1 protein, rat
  • Nr4a3 protein, mouse
  • Nr4a3 protein, rat
  • Nuclear Proteins
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • Nuclear Receptor Subfamily 4, Group A, Member 1
  • Protein Isoforms
  • Proto-Oncogene Proteins c-bcl-2
  • RORC protein, human
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Retinoic Acid
  • Receptors, Steroid
  • Receptors, Thyroid Hormone
  • Rorc protein, mouse
  • Rorc protein, rat
  • Transcription Factors
  • bcl-X Protein