Medication adherence of individuals with a first episode of psychosis

Acta Psychiatr Scand. 2002 Oct;106(4):286-90. doi: 10.1034/j.1600-0447.2002.02437.x.


Objective: To determine rates of adherence to antipsychotic medication in first episode patients and the correlates of adherence in this group.

Method: Subjects were the first 200 admissions to an Early Psychosis Program. Adherence was determined on a three-point scale. Symptoms, medication side-effects, quality of life, substance use and family involvement were examined longitudinally.

Results: In their first year in the program 39% were non-adherent, 20% inadequately adherent, and 41% adherent. Non-adherent patients demonstrated more positive symptoms, more relapses, more alcohol and cannabis use, reduced insight, and poorer quality of life. They were younger, had an earlier age of onset and less likely to have a family member involved in treatment.

Conclusion: Results for this group are similar to those reported in the literature. Correlates are often the consequence of non-adherence. Non-compliance has to be anticipated and relationships maintained with patients and families to intervene as soon as possible to minimize the consequence of non-compliance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Patient Compliance / statistics & numerical data*
  • Quality of Life
  • Schizophrenia / drug therapy*
  • Substance-Related Disorders / epidemiology


  • Antipsychotic Agents