[Effect of a drug composition containing pyroglutamic acid and pyrrolidone on the cerebral circulation]

Eksp Klin Farmakol. 2002 May-Jun;65(3):3-5.
[Article in Russian]


A drug composition containing pyroglutamic acid and pyrrolidone produces a significant effect on the cerebral circulation in rats and cats, which is manifested by increased cerebral blood flow and by a dose-independent improvement of the microcirculation. The cerebrovascular effects were similarly pronounced in both rats and cats which indicates that the drug action is independent of the animal species. The drug combination studied did not exhibit antiserotonin activity. The data obtained show evidence of a substantial contribution of the cerebrovascular component to the neuroprotector action of the drug composition studied.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Cats
  • Cerebrovascular Circulation / drug effects*
  • Drug Interactions
  • Microcirculation
  • Neuroprotective Agents / pharmacology*
  • Pyrrolidinones / pharmacology*
  • Pyrrolidonecarboxylic Acid / pharmacology*
  • Rats


  • Neuroprotective Agents
  • Pyrrolidinones
  • Pyrrolidonecarboxylic Acid