Familial dyslexia: neurocognitive and genetic correlation in a large Finnish family

Dev Med Child Neurol. 2002 Sep;44(9):580-6. doi: 10.1017/s0012162201002614.

Abstract

Neuropsychological findings of individuals with dyslexia (n=24) from a large, three-generation Finnish family are presented. We have previously performed whole genome linkage scanning in this family and found that dyslexia in this kindred segregates with a single locus in the pericentromeric area of chromosome 3. Those included in the analyses were carefully evaluated for general cognitive ability, reading and spelling skills, and reading-related neurocognitive skills. The neurocognitive type of dyslexia segregating in this family consisted of deficits in phonological awareness, verbal short-term memory, and rapid naming. Severe dyslexia also seemed to be connected with a general language difficulty and was most common in the eldest generation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Child
  • Cognition Disorders / genetics*
  • Dyslexia / genetics*
  • Dyslexia / physiopathology*
  • Female
  • Finland
  • Humans
  • Language Disorders / genetics*
  • Male
  • Memory
  • Neuropsychological Tests
  • Pedigree