Abstract
An efficient, convergent synthesis of the C1'-C11' side chain (3) of leucascandrolide A (1) has been achieved. The key bond connection is made through the use of a palladium(0)-catalyzed Sonogashira cross-coupling between trifloyl oxazole (4) and alkynylmetal species (5).
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkynes / chemistry*
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Animals
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Catalysis
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Cross-Linking Reagents / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Organometallic Compounds / chemistry
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Oxazoles / chemistry*
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Palladium / chemistry*
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Porifera / chemistry*
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / chemistry
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Structure-Activity Relationship
Substances
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Alkynes
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Cross-Linking Reagents
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Organometallic Compounds
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Oxazoles
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Sesquiterpenes
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leucascandrolide A
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Palladium