Evaluation of a commercial PET tomograph-based system for the quantitative assessment of rCBF, rOEF and rCMRO2 by using sequential administration of 15O-labeled compounds

Ann Nucl Med. 2002 Jul;16(5):317-27. doi: 10.1007/BF02988616.


The purpose of this study was to develop a reliable and practical strategy that generates quantitative CBF and OEF maps accurately from PET data sets obtained with 15O-tracers. Sequential sinogram data sets were acquired after the administration of 15O-tracers, and combined single-frame images were obtained. The delay time between sampled input function and the brain was estimated from the H2(15)O study with the whole brain and the arterial time-activity curves (TACs). The whole-brain TACs were obtained from the reconstructed images (image-base method) and the sinogram data (sinogram-base method). Six methods were also evaluated for the dead-time and decay correction procedures in the process of generating a single-frame image from the dynamic sinogram. The estimated delay values were similar with both the sinogram-based and image-based methods. A lumped correction factor to a previously added single-frame sinogram caused an underestimation of CBF, OEF and CMRO2 by 16% at maximum, as compared with the correction procedure for a short sinogram. This suggested the need for a dynamic acquisition of a sinogram with a short interval. The proposed strategy provided an accurate quantification of CBF and OEF by PET with 15O-tracers.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Algorithms
  • Blood Volume Determination / methods
  • Brain / blood supply
  • Brain / diagnostic imaging*
  • Brain / physiology*
  • Cerebrovascular Circulation*
  • Humans
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods*
  • Male
  • Oxygen / metabolism
  • Oxygen Consumption
  • Oxygen Radioisotopes* / classification
  • Radiopharmaceuticals
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, Emission-Computed / instrumentation*
  • Tomography, Emission-Computed / methods


  • Oxygen Radioisotopes
  • Radiopharmaceuticals
  • Oxygen