Translating axon guidance cues

Cell. 2002 Sep 6;110(5):537-40. doi: 10.1016/s0092-8674(02)00934-0.


Recent studies suggest that local translation of mRNA within axons plays a key role in two aspects of growth cone navigation. One line of evidence implies a local synthesis of proteins that mediate growth cone collapse and turning in response to guidance cues; another indicates that growth cones possess the machinery that would allow the local synthesis of receptors for axon guidance cues.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / metabolism*
  • Growth Cones / physiology*
  • Membrane Proteins / biosynthesis
  • Protein Biosynthesis*
  • Signal Transduction


  • Membrane Proteins