Desmosomal cadherins

Curr Opin Cell Biol. 2002 Oct;14(5):537-45. doi: 10.1016/s0955-0674(02)00366-6.


New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cadherins / chemistry*
  • Cell Adhesion
  • Desmosomes / metabolism*
  • Epidermis / metabolism*
  • Genotype
  • Humans
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Phenotype
  • Protein Binding


  • Cadherins