The cell surface: the stage for matrix metalloproteinase regulation of migration

Curr Opin Cell Biol. 2002 Oct;14(5):624-32. doi: 10.1016/s0955-0674(02)00363-0.


Matrix metalloproteinases are important for the turnover of extracellular matrix in tissue. Recent studies have expanded their roles well beyond extracellular matrix degradation - they also cleave many growth factors, cytokines and cell adhesion molecules in the extracellular milieu, modulating their functions irreversibly. In particular, some matrix metalloproteinases that associate with the cell surface have arisen as intriguing regulators of cellular functions, including migration.

Publication types

  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Cell Membrane / metabolism*
  • Cell Movement
  • Cytoplasm / metabolism
  • Extracellular Matrix / metabolism
  • Humans
  • Matrix Metalloproteinases / metabolism*
  • Matrix Metalloproteinases, Membrane-Associated
  • Metalloendopeptidases / metabolism
  • Models, Biological


  • Actins
  • Matrix Metalloproteinases
  • Matrix Metalloproteinases, Membrane-Associated
  • Metalloendopeptidases