Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis

J Infect Dis. 2002 Oct 1;186(7):1013-8. doi: 10.1086/342956. Epub 2002 Aug 29.


Filgrastim, or granulocyte colony-stimulating factor, reverses neutropenia associated with human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV) infections. During a trial of anti-CMV retinitis therapies coadministered with antiretroviral therapy, 2-4 plasma specimens of HIV-1 RNA were collected from 36 HIV-1-infected patients receiving filgrastim to prevent neutropenia and from 36 patients not receiving filgrastim. For both groups, the crude mean and mean rate of change of HIV-1 log(10) RNA levels were similar. Adjustment for covariates (CD4(+) T cell lymphocytes, virus load at enrollment, level of neutropenia and antiretroviral therapy [mainly non-highly active antiretroviral therapy], and anti-CMV therapy during follow-up) resulted in a mean log(10) HIV-1 RNA level for individuals receiving filgrastim versus those not receiving the drug of 5.11 versus 4.87 (P=.12) and respective log mean rates of change per month of -0.08 versus -0.21 (P=.08). This latter difference has borderline statistical significance, which suggests that filgrastim may reduce the decline of HIV-1 RNA loads.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS-Related Opportunistic Infections / blood
  • AIDS-Related Opportunistic Infections / complications
  • AIDS-Related Opportunistic Infections / drug therapy*
  • Adult
  • Antiviral Agents / therapeutic use*
  • Cohort Studies
  • Cytomegalovirus Retinitis / blood
  • Cytomegalovirus Retinitis / drug therapy*
  • Cytomegalovirus Retinitis / etiology
  • Drug Therapy, Combination
  • Female
  • Filgrastim
  • Follow-Up Studies
  • Granulocyte Colony-Stimulating Factor / therapeutic use*
  • HIV-1* / drug effects
  • HIV-1* / genetics
  • Humans
  • Male
  • Neutropenia / etiology
  • Neutropenia / prevention & control
  • RNA, Viral / blood*
  • Recombinant Proteins
  • Treatment Outcome
  • Viral Load


  • Antiviral Agents
  • RNA, Viral
  • Recombinant Proteins
  • Granulocyte Colony-Stimulating Factor
  • Filgrastim