Placental transfer of ganciclovir in a woman with acquired immunodeficiency syndrome and cytomegalovirus disease

Pediatr Infect Dis J. 2002 Aug;21(8):796-7. doi: 10.1097/00006454-200208000-00023.

Abstract

A pregnant woman with AIDS developed cytomegalovirus (CMV) retinitis and pneumonitis, requiring intravenous ganciclovir. At 34 weeks gestation the woman delivered a 1.4-kg girl. Examination of the placenta revealed transplacental passage of CMV. Low concentrations of ganciclovir were detected in the neonate's plasma. The neonate had mild anemia but no other signs of congenital CMV infection.

Publication types

  • Case Reports

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Antiviral Agents / blood
  • Antiviral Agents / therapeutic use
  • Cytomegalovirus / isolation & purification
  • Cytomegalovirus Infections / blood*
  • Cytomegalovirus Infections / complications
  • Cytomegalovirus Infections / drug therapy*
  • Cytomegalovirus Infections / transmission
  • Female
  • Ganciclovir / blood*
  • Ganciclovir / therapeutic use*
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical
  • Maternal-Fetal Exchange*
  • Pregnancy

Substances

  • Antiviral Agents
  • Ganciclovir