Carbapenem-resistant Pseudomonas aeruginosa in malaysia producing IMP-7 beta-lactamase

Siaw Eng Ho; Geetha Subramaniam; Selvi Palasubramaniam; Parasakthi Navaratnam

doi:10.1128/AAC.46.10.3286-3287.2002

Carbapenem-resistant Pseudomonas aeruginosa in malaysia producing IMP-7 beta-lactamase

Antimicrob Agents Chemother. 2002 Oct;46(10):3286-7. doi: 10.1128/AAC.46.10.3286-3287.2002.

Authors

Siaw Eng Ho¹, Geetha Subramaniam, Selvi Palasubramaniam, Parasakthi Navaratnam

Affiliation

¹ Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Abstract

We have isolated and identified a carbapenem-resistant Pseudomonas aeruginosa strain from Malaysia that produces an IMP-7 metallo-beta-lactamase. This isolate showed high-level resistance to meropenem and imipenem, the MICs of which were 256 and 128 micro g/ml, respectively. Isoelectric focusing analyses revealed pI values of >9.0, 8.2, and 7.8, which indicated the possible presence of IMP and OXA. DNA sequencing confirmed the identity of the IMP-7 determinant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Carbapenems / pharmacology*
Child
Humans
Imipenem / pharmacology
Malaysia
Meropenem
Microbial Sensitivity Tests
Pseudomonas aeruginosa / drug effects
Pseudomonas aeruginosa / enzymology*
Thienamycins / pharmacology
beta-Lactam Resistance*
beta-Lactamases / genetics
beta-Lactamases / metabolism*

Substances

Anti-Bacterial Agents
Carbapenems
Thienamycins
Imipenem
beta-Lactamases
Meropenem