Effectiveness of chlorhexidine-thymol varnish for caries reduction in permanent first molars of 6-7-year-old children: 24-month clinical trial

Community Dent Oral Epidemiol. 2002 Oct;30(5):363-8. doi: 10.1034/j.1600-0528.2002.00061.x.


Objectives: To determine the effect of chlorhexidine varnish on the prevention of caries in permanent first molars.

Methods: Two groups of 6-7-year-old school children were followed up in a clinical trial, a group of 86 children whose teeth were treated with a chlorhexidine-thymol varnish (Cervitec) and a control group of 95 children. The varnish was reapplied every 3 months and the caries increments were compared at 24 months.

Results: The DFS (decayed and filled surfaces in permanent first molars) increment in the control group (mean = 1.85; SD = 2.27) was higher than in the test group (mean = 0.95; SD = 1.38), resulting in a 48.6% caries reduction. This difference was statistically significant (P = 0.032).

Conclusions: Chlorhexidine-thymol varnish is effective in preventing caries in permanent first molars.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents, Local / therapeutic use*
  • Child
  • Chlorhexidine / therapeutic use*
  • DMF Index
  • Dental Caries / prevention & control*
  • Drug Combinations
  • Female
  • Humans
  • Lacquer
  • Male
  • Statistics, Nonparametric
  • Thymol / therapeutic use*


  • Anti-Infective Agents, Local
  • Drug Combinations
  • chlorhexidine, thymol drug combination
  • Thymol
  • Chlorhexidine