Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel

Skin Res Technol. 2002 Aug;8(3):164-7. doi: 10.1034/j.1600-0846.2002.10295.x.


Background/aims: Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE.

Methods: In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured.

Results: Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness.

Conclusion: The DMAE formulation under investigation increased skin firmness.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anisotropy
  • Deanol / pharmacology*
  • Dermatologic Agents / pharmacology*
  • Dermatology / methods
  • Double-Blind Method
  • Female
  • Gels
  • Humans
  • Middle Aged
  • Pharmaceutical Vehicles / pharmacology
  • Pilot Projects
  • Skin / drug effects
  • Skin Physiological Phenomena / drug effects*
  • Suction
  • Tensile Strength


  • Dermatologic Agents
  • Gels
  • Pharmaceutical Vehicles
  • Deanol