Massive OxyContin ingestion refractory to naloxone therapy

Ann Emerg Med. 2002 Oct;40(4):425-8. doi: 10.1067/mem.2002.128143.


OxyContin (oxycodone hydrochloride controlled release) is a long-acting preparation of oxycodone that is used as an opioid analgesic to treat chronic pain conditions. We report a patient who ingested a massive quantity of OxyContin and had altered mental status, noncardiogenic pulmonary edema, and hypoventilation that proved refractory to naloxone administration. She required mechanical ventilation for 3 days before recovering completely. The severity and length of poisoning was likely related both to the quantity and formulation of the oxycodone ingested.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Middle Aged
  • Naloxone / therapeutic use*
  • Narcotic Antagonists / therapeutic use*
  • Narcotics / poisoning*
  • Oxycodone / antagonists & inhibitors
  • Oxycodone / poisoning*
  • Respiration, Artificial
  • Severity of Illness Index
  • Suicide, Attempted
  • Treatment Outcome


  • Narcotic Antagonists
  • Narcotics
  • Naloxone
  • Oxycodone