Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons

J Assoc Res Otolaryngol. 2003 Mar;4(1):74-82. doi: 10.1007/s10162-002-2039-5. Epub 2002 Sep 23.


The detection of odorants with high sensitivity and specificity utilizes specialized transduction proteins that may be assembled into complexes to afford enhanced speed and efficiency in olfactory neurons. We have used a differential cDNA screening technique to identify novel gene products that display restricted expression within the olfactory epithelium. Here we report the characterization of an olfactory neuronal protein, SLP3, which shares extensive homology with the stomatin family of membrane proteins. Other stomatin family members have been implicated in specific interactions with ion channels and G protein-coupled receptors. The pattern of SLP3 mRNA expression during embryonic development and the subcellular localization of the SLP3 protein in mature olfactory neurons observed here is consistent with a specific role for this protein in the assembly, translocation, or function of the odorant transduction complex in olfactory neurons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blood Proteins / chemistry
  • Blood Proteins / genetics
  • Calcium-Binding Proteins / genetics
  • DNA, Complementary / genetics
  • Gene Expression Regulation, Developmental / genetics*
  • In Situ Hybridization
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics*
  • Mice
  • Molecular Sequence Data
  • Multigene Family
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / genetics*
  • Olfactory Pathways / physiology
  • Olfactory Receptor Neurons / physiology*
  • RNA, Messenger / genetics
  • Rats
  • Sequence Alignment
  • Sequence Homology, Amino Acid


  • Blood Proteins
  • Calcium-Binding Proteins
  • DNA, Complementary
  • Epb7.2 protein, mouse
  • Membrane Proteins
  • Nerve Tissue Proteins
  • RNA, Messenger
  • STOML3 protein, human
  • Stoml3 protein, mouse