Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 55 (7), 623-8

kynapcin-13 and -28, New Benzofuran Prolyl Endopeptidase Inhibitors From Polyozellus Multiplex

Affiliations

kynapcin-13 and -28, New Benzofuran Prolyl Endopeptidase Inhibitors From Polyozellus Multiplex

Sang-In Kim et al. J Antibiot (Tokyo).

Abstract

Two new benzofurans, 5,6-dihydroxybenzofuran-2,3-dicarboxylic acid dimethyl ester (kynapcin-13) and 5,6,5',6'-tetrahydroxy[3,3']bibenzofuranyl-2,2'-dicarboxylic acid 2'-methyl ester (kynapcin-28) were isolated from Polyozellus multiplex, and shown to non-competitively inhibit prolyl endopeptidase (PEP), with the IC50 values of 76.80 and 0.98 microM, respectively. Kynapcin-13 and -28 were less inhibitory to other serine proteases such as chymotrypsin, trypsin, and elastase.

Similar articles

See all similar articles

Cited by 2 articles

Publication types

MeSH terms

Feedback