Biogenesis of lamellar bodies, lysosome-related organelles involved in storage and secretion of pulmonary surfactant

Semin Cell Dev Biol. 2002 Aug;13(4):263-70. doi: 10.1016/s1084952102000551.


Lamellar bodies are members of a subclass of lysosome-related organelles referred to as secretory lysosomes. The principal constituents of the lamellar body, surfactant phospholipids, are organized into tightly packed, bilayer membranes in a process that is strongly influenced by the lung-specific, hydrophobic peptide SP-B. Newly synthesized SP-B is transported from the Golgi to the lamellar body via multivesicular bodies; in contrast, preliminary evidence suggests that newly synthesized surfactant phospholipids are transported from the ER and incorporated into the internal membranes of the lamellar body via a distinct pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Lung / cytology
  • Lung / metabolism
  • Lysosomes / metabolism*
  • Lysosomes / ultrastructure
  • Pulmonary Surfactants / metabolism*
  • Secretory Vesicles / metabolism*
  • Secretory Vesicles / ultrastructure


  • Pulmonary Surfactants