PIP: The clinical indications for Prostin E2 (dinoprostone, a synthetic prostaglandin) are enumerated. In obstetrics and gynecology, the smooth muscle properties, similar to those of oxytocin, make Prostin E2 a viable alternative to oxytocin for similar indications. For labor induction, Prostin E2 is 90% effective in late pregnancy when infused intravenously. A final concentration of 1.5 mcgm/ml is sufficient for labor induction, except in the case of fetal death in utero where higher drug concentrations are required to expel the fetus. Prostin E2 is preferable to oxytocin for labor induction because of its narrower dose range and lack of serious side effects. Prostin E2 is also indicated for medical termination of pregnancy, So far clinical experience indicates that Prostin E2 administered by the intrauterine, extraamniotic route is more effective and better tolerated than the intravenous route. In second trimester abortions, the drug, administered extraamniotically, has been effective in 90% of cases vs. 70% effectiveness with intravenous infusion. The initial extraamniotic instillation should be 1 ml, and subsequent instillations can range from 1-2 ml. The initial intravenous infusion should be 2.5 mcgm for 30 minutes increased stepwise to 5 mcgm/minute. Side effects are the same but of greater severity via intravenous infusion. The use of Prostin E2 as a morning after contraceptive is discussed.