A review with 114 references about mammalian lignans (enterolignans). Several aspects have been reviewed: the precursors of mammalian lignans and their biosynthesis, biological activities and health effects, metabolism (in vivo and in vitro) in human and animals, some synthetic strategies to obtain enterolignan skeleton types, including the synthesis of haptens and deuterated lignans, and finally an overview of the analytical methods to detect and quantify lignans in biological matrices and foods.