Inactivation of Thyroid Peroxidase by Soy Isoflavones, in Vitro and in Vivo

J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Sep 25;777(1-2):269-79. doi: 10.1016/s1570-0232(02)00214-3.


Soy-containing foods and dietary supplements are widely consumed for putative health benefits (e.g. cancer chemoprevention, beneficial effects on serum lipids associated with cardiovascular health, reduction of osteoporosis, relief of menopausal symptoms). However, studies of soy isoflavones in experimental animals suggest possible adverse effects as well (e.g. enhancement of reproductive organ cancer, modulation of endocrine function, anti-thyroid effects). This paper reviews the evidence in humans and animals for anti-thyroid effects of soy and its principal isoflavones, genistein and daidzein.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antithyroid Agents / pharmacology
  • Diet
  • Enzyme Inhibitors / pharmacology*
  • In Vitro Techniques
  • Iodide Peroxidase / antagonists & inhibitors*
  • Isoflavones / administration & dosage
  • Isoflavones / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Soybeans / chemistry*
  • Thyroid Hormones / biosynthesis


  • Antithyroid Agents
  • Enzyme Inhibitors
  • Isoflavones
  • Thyroid Hormones
  • Iodide Peroxidase