Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker

Brain Res. 2002 Oct 4;951(2):336-40. doi: 10.1016/s0006-8993(02)03350-4.


Voltage-gated Ca(2+) channels play a crucial role in pain perception. We studied the antinociceptive potential of systemically administered mibefradil, a peripherally acting antihypertensive agent and preferential T-type Ca(2+) channel blocker. Systemic injections of mibefradil, in clinically relevant doses, induced mechanical and thermal antinociception in adult rats without compromising their sensorimotor abilities. This suggests that peripherally acting T-type Ca(2+) channel blockers can be useful antinociceptive agents.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analgesics*
  • Animals
  • Calcium Channel Blockers / pharmacology*
  • Calcium Channels, T-Type / drug effects*
  • Dose-Response Relationship, Drug
  • Female
  • Hot Temperature
  • Injections, Intraperitoneal
  • Mibefradil / pharmacology*
  • Pain Measurement / drug effects
  • Physical Stimulation
  • Rats
  • Rats, Sprague-Dawley


  • Analgesics
  • Calcium Channel Blockers
  • Calcium Channels, T-Type
  • Mibefradil