The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13148-53. doi: 10.1073/pnas.192319099. Epub 2002 Sep 23.


The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alphaproteobacteria / genetics
  • Brucella / genetics*
  • Brucella / pathogenicity
  • Brucella melitensis / genetics
  • Chromosomes, Bacterial / ultrastructure
  • DNA Transposable Elements
  • Genome, Bacterial*
  • Models, Genetic
  • Molecular Sequence Data
  • Open Reading Frames
  • Rhizobium / genetics


  • DNA Transposable Elements

Associated data

  • PIR/AE014291
  • PIR/AE014292