Does diabetes affect [(18)F]FDG standardised uptake values in lung cancer?

Eur J Nucl Med Mol Imaging. 2002 Oct;29(10):1324-7. doi: 10.1007/s00259-002-0887-1. Epub 2002 Aug 10.


The correlation of hyperglycaemia with decreased 2-[(18)F]fluoro-2-deoxy- D-glucose (FDG) uptake by tumours in positron emission tomography (PET) imaging has been clearly established. The available data are mainly based on non-diabetic (non-DM) patients exposed to acute hyperglycaemia after glucose infusion, and little is known about the effect of diabetes mellitus (DM) on FDG uptake by tumours. In this retrospective study we performed a comparison of the tumour uptake in 40 DM patients with the tumour uptake in 145 non-DM patients, all with primary lung malignancies. Peak standardised uptake values (SUVs) without glucose correction were calculated for the lung lesions. Mean (+/-standard deviation) blood glucose concentrations were 6.58+/-2.46 mmol/l in the DM patients and 4.39+/-0.89 mmol/l in the non-DM patients. There was no significant difference between tumour SUVs in DM patients (79 lesions), 5.86+/-3.97, and those in non-DM patients (234 lesions), 6.47+/-4.61. There was no significant difference between tumour SUVs in DM patients with blood glucose <7 mmol/l ( n=28, 64 lesions), 5.91+/-3.98, and those in DM patients with blood glucose >7 mmol/l ( n=12, 15 lesions), 5.68+/-4.09. There was also no significant difference between myocardial SUVs in the DM patients ( n=40), 3.28+/-2.75, and in a similar group of non-DM patients ( n=42), 3.30+/-2.24. We conclude that FDG uptake in lung tumours is not significantly influenced by blood glucose levels in diabetic patients whose blood glucose levels are reasonably well controlled.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Glucose / analysis
  • Diabetes Complications*
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / metabolism*
  • Female
  • Fluorodeoxyglucose F18 / pharmacokinetics*
  • Fluorodeoxyglucose F18 / standards
  • Humans
  • Lung Neoplasms / blood
  • Lung Neoplasms / complications*
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / metabolism*
  • Male
  • Middle Aged
  • Quality Control
  • Radionuclide Imaging
  • Radiopharmaceuticals / pharmacokinetics
  • Radiopharmaceuticals / standards
  • Reference Standards
  • Reference Values
  • Reproducibility of Results
  • Retrospective Studies
  • Sensitivity and Specificity
  • Statistics as Topic
  • Tissue Distribution


  • Blood Glucose
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18