Cervical priming before first trimester aspiration abortion: a single blind study comparing gemeprost 1 mg and prostaglandin E2 10 mg pessaries

J Obstet Gynaecol (Lahore). 1990 Oct;10(6):513-7. doi: 10.3109/01443619009151257.


PIP: 1030 patients were studied in 1 of the largest single center prospective random trials which assessed the effects of 2 prostaglandin (PG) vaginal pessaries on cervical dilatation and compliance during 1st trimester abortion by uterine aspiration under general anesthesia. Gemeprost 1 mg pessaries inserted 1-4 hours prior to surgery produced marginally greater cervical dilatation and less operative blood loss than PGE2 10 mg pessaries with a reduction in distressing preoperative side effects. No reduction in effect on the cervix was ascertained if pessaries were inserted for only 1-2 hours as compared with 3-4 hours. Postoperative side effects and later complications were infrequent and similar with both preparations. Gemeprost 1 mg pessaries are thus preferable to PGE2 10 mg pessaries for this purpose.

MeSH terms

  • Abortifacient Agents*
  • Abortion, Induced*
  • Biology
  • Birth Rate
  • Cervix Uteri*
  • Demography
  • Developed Countries
  • Disease
  • Endocrine System
  • Europe
  • Family Planning Services
  • Fertility
  • Genitalia
  • Genitalia, Female
  • Hemorrhage*
  • Incidence*
  • Parity*
  • Physiology
  • Population
  • Population Dynamics
  • Pregnancy
  • Pregnancy Trimester, First*
  • Prospective Studies*
  • Prostaglandins*
  • Reproduction
  • Research
  • Research Design
  • Signs and Symptoms
  • United Kingdom
  • Urogenital System
  • Uterine Perforation*
  • Uterus


  • Abortifacient Agents
  • Prostaglandins