The effects of acute phase proteins on serum albumin, transferrin and haemoglobin in haemodialysis patients

Int J Clin Pract. 2002 Sep;56(7):505-8.


In the present study, the effects of C-reactive protein (CRP) and ferritin on serum albumin, transferrin and haemoglobin (Hb) were assessed to investigate the relationship between inflammation, hypoalbuminaemia and anaemia in haemodialysis patients. A total of 117 patients who were followed at three haemodialysis units in Kocaeli were enrolled. The mean age was 47.83 +/- 16.85 years. The median time on dialysis was 26 (minimum 1, maximum 209) months. Serum CRP albumin and ferritin concentrations were measured in our laboratory and transferrin, urea reduction ratio (URR) and Kt/V were calculated. There was significant inverse correlation between serum CRP level and albumin (p<0.001), serum CRP and Hb (p<0.001), and serum transferrin and ferritin (p<0.05). There was significant positive correlation between serum albumin and Hb (p<0.001), serum CRP and ferritin (p<0.05), and transferrin and URR (p<0.05). Our findings suggest that inflammation is a contributor in the development of hypoalbuminaemia and anaemia in haemodialysis patients as well as malnutrition and inadequate dialysis.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anemia / blood
  • Anemia / diagnosis
  • Anemia / etiology*
  • C-Reactive Protein / administration & dosage*
  • Female
  • Ferritins / administration & dosage*
  • Hemoglobins / metabolism
  • Humans
  • Male
  • Middle Aged
  • Nutritional Status
  • Prospective Studies
  • Renal Dialysis / adverse effects*
  • Serum Albumin / deficiency*
  • Serum Albumin / drug effects
  • Transferrin / metabolism


  • Hemoglobins
  • Serum Albumin
  • Transferrin
  • C-Reactive Protein
  • Ferritins