A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening

J Am Chem Soc. 2002 Oct 2;124(39):11608-9. doi: 10.1021/ja026720i.

Abstract

The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor / methods
  • Microtubules / drug effects*
  • Purines / chemistry
  • Purines / pharmacology
  • Structure-Activity Relationship
  • Triazines / chemical synthesis*
  • Triazines / chemistry
  • Triazines / pharmacology*
  • Zebrafish / embryology*

Substances

  • Antineoplastic Agents
  • Purines
  • Triazines
  • myoseverin