Effects of norandrostenedione and norandrostenediol in resistance-trained men

Nutrition. 2002 Sep;18(9):734-7. doi: 10.1016/s0899-9007(02)00834-1.

Abstract

The purpose of this study was to determine the effects of norsteroid supplementation (224 mg of 19-nor-4-androstene-3,17-dione and 120 mg of 19-nor-4-androstene-3,17-diol, total daily dose = 344 mg) on body composition and strength in resistance-trained men. In a placebo-controlled, double-blind, randomized fashion, 10 subjects received the norsteroid (11 capsules containing a combination of both norsteroids) or a placebo for 8 wk (five subjects per group). Each subject participated in resistance training an average of 4 d/wk for the duration of the study. Body composition was determined via dual-energy x-ray absorptiometry. Strength was determined using a one-repetition maximum bench press and a one-repetition maximum biceps curl. With regard to all measures in both groups, there were no significant changes between before and after the study.Therefore, in this small sample of resistance-trained men, 344 mg/d of norsteroid supplementation had no effect on strength or body composition.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Absorptiometry, Photon / methods
  • Adult
  • Androstenediols / administration & dosage
  • Androstenediols / pharmacology*
  • Androstenedione / administration & dosage
  • Androstenedione / analogs & derivatives*
  • Androstenedione / pharmacology*
  • Body Composition / drug effects*
  • Dietary Supplements
  • Double-Blind Method
  • Humans
  • Male
  • Treatment Outcome
  • Weight Lifting*

Substances

  • 19-nor-4-androstene-3,17-diol
  • Androstenediols
  • Androstenedione
  • 19-norandrostenedione