Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?

FEBS Lett. 2002 Sep 25;528(1-3):3-4. doi: 10.1016/s0014-5793(02)03248-9.


A gene family containing a longevity assurance gene (Lag1p) motif is described. Database searches revealed >40 members of this family of transmembrane proteins, two of which have recently been shown to regulate the synthesis of ceramide, a lipid second messenger involved in a variety of cellular processes. We speculate that other family members, some of which contain a Hox domain, may also be involved in the synthesis of specific ceramide pools, perhaps explaining the role of longevity assurance genes in regulating development.

MeSH terms

  • Animals
  • Ceramides / biosynthesis*
  • Genes, Fungal
  • Genes, Homeobox*
  • Humans
  • Longevity / genetics*
  • Models, Biological*
  • Multigene Family
  • Phylogeny
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae / metabolism
  • Signal Transduction


  • Ceramides