Predictors of effective bilateral subthalamic nucleus stimulation for PD

P D Charles; N Van Blercom; P Krack; S L Lee; J Xie; G Besson; A-L Benabid; P Pollak

doi:10.1212/wnl.59.6.932

Predictors of effective bilateral subthalamic nucleus stimulation for PD

Neurology. 2002 Sep 24;59(6):932-4. doi: 10.1212/wnl.59.6.932.

Authors

P D Charles¹, N Van Blercom, P Krack, S L Lee, J Xie, G Besson, A-L Benabid, P Pollak

Affiliation

¹ Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France.

PMID: 12297584
DOI: 10.1212/wnl.59.6.932

Abstract

To identify factors predictive of effective bilateral subthalamic nucleus (STN) stimulation for PD with severe motor complications, pre- and postoperative Unified PD Rating Scale (UPDRS) scores were analyzed in a series of 54 patients who received bilateral STN stimulation. Younger age and levodopa responsiveness predict a favorable response to bilateral STN stimulation. For individual PD symptoms, those that improve with a suprathreshold dose levodopa challenge are likely to improve with stimulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Age Factors
Aged
Electric Stimulation Therapy / methods
Electric Stimulation Therapy / statistics & numerical data*
Female
Humans
Levodopa / therapeutic use
Male
Middle Aged
Multivariate Analysis
Parkinson Disease / drug therapy
Parkinson Disease / physiopathology
Parkinson Disease / surgery*
Preoperative Care / statistics & numerical data
Regression Analysis
Statistics, Nonparametric
Subthalamic Nucleus / surgery*

Substances

Levodopa