Peptide-mediated cell delivery: application in protein target validation

Curr Opin Pharmacol. 2002 Oct;2(5):587-94. doi: 10.1016/s1471-4892(02)00199-6.

Abstract

Recent reports have suggested that conjugation of peptides, proteins and antisense to short highly basic peptides, such as TAT, antennapedia and transportan, results in their rapid translocation into cells. Importantly, these conjugates have been shown to exert actions in a number of animal models suggesting their general utility for the determination of protein function in vitro and in vivo.

Publication types

  • Review

MeSH terms

  • Animals
  • Antisense Elements (Genetics) / administration & dosage
  • Cells
  • Drug Delivery Systems*
  • Humans
  • Peptides / administration & dosage
  • Peptides / metabolism
  • Peptides / physiology*
  • Proteins / administration & dosage
  • Proteins / metabolism
  • Receptors, Drug / metabolism
  • Signal Transduction / drug effects
  • Signal Transduction / physiology

Substances

  • Antisense Elements (Genetics)
  • Peptides
  • Proteins
  • Receptors, Drug