[Calcified pseudotumor of the pleura: description of a case]

Pathologica. 2002 Aug;94(4):201-5. doi: 10.1007/s102420200032.
[Article in Italian]


We describe a calcifying fibrous pseudotumour of pleura in a 46-year-old female, smoker. The patient presented with a well-delimited pleural mass, 3-cm across, located at the base of the right lung and attached to the lung with a short pedicle. Seven years after surgical excision of the mass, the patient is alive and well. Microscopically, the lesion was mostly composed of dense collagenous tissue, with sparse benign spindle cells, a rich inflammatory infiltrate and scattered calcifications, sometimes laminated. Immunohistochemically, spindle cells were positive for vimentin and negative for smooth muscle actin, desmin, S100 protein, CD34, CD99 and Bcl2. Calcifying fibrous pseudotumour is rare in the pleura. Pertinent data from the literature and problems in differential diagnosis are briefly discussed.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • Antigens, CD / analysis
  • Biomarkers
  • Calcinosis / diagnosis
  • Calcinosis / metabolism
  • Calcinosis / pathology*
  • Cytoskeletal Proteins / analysis
  • Diagnosis, Differential
  • Female
  • Granuloma, Plasma Cell / diagnosis
  • Granuloma, Plasma Cell / metabolism
  • Granuloma, Plasma Cell / pathology*
  • Humans
  • Immunoglobulin Light Chains / analysis
  • Middle Aged
  • Pleural Diseases / diagnosis
  • Pleural Diseases / metabolism
  • Pleural Diseases / pathology*
  • Pleural Neoplasms / diagnosis
  • Proto-Oncogene Proteins c-bcl-2 / analysis
  • S100 Proteins / analysis


  • Antigens, CD
  • Biomarkers
  • Cytoskeletal Proteins
  • Immunoglobulin Light Chains
  • Proto-Oncogene Proteins c-bcl-2
  • S100 Proteins