Zinc depletion and menorrhagia in Nigerians using copper T-200 intrauterine device

Trace Elem Med. 1989;6(4):147-9.


PIP: A 12-month followup study was undertaken to evaluate the effect of using the copper T-200 IUD on hemoglobin in trace element levels in Nigerian women. A total of 45 women were studied, including 20 who were using that IUD and 25 controls. The results indicated that after 12 months, the mean serum zinc and iron levels in the study group were significantly lower (p0.01) than initial concentrations and that of normal nonusers. This was true for both hemoglobin and hematocrit values (p0.05). However, serum copper increased significantly in the study group (p0.01). It is suggested that the low zinc status was probably responsible for the menorrhagia which was common among the study group using copper IUDs, which in turn was responsible for the anemia seen in more than 50% of the IUD users. However, the decreased in iron and zinc as well as the increase in copper levels may be a result of alterations during the acute phase response associated with the insertion of the Cu T-200. The monitoring of hemoglobin and serum iron levels as well as zinc levels may thus enhance the prophylactic use of IUDs to control menorrhagia, which leads ultimately to the development of anemia in this group.

MeSH terms

  • Africa
  • Africa South of the Sahara
  • Africa, Western
  • Biology
  • Blood
  • Clinical Laboratory Techniques
  • Contraception
  • Copper*
  • Developing Countries
  • Diagnosis
  • Disease
  • Family Planning Services
  • Follow-Up Studies*
  • Hematocrit*
  • Hemoglobins*
  • Intrauterine Devices
  • Intrauterine Devices, Copper*
  • Menorrhagia*
  • Menstruation Disturbances
  • Nigeria
  • Physiology
  • Prevalence*
  • Research
  • Research Design*
  • Zinc*


  • Hemoglobins
  • Copper
  • Zinc