Changes in drug metabolism with increasing age: 1. warfarin binding and plasma proteins

Br J Clin Pharmacol. 1975 Feb;2(1):69-72. doi: 10.1111/j.1365-2125.1975.tb00474.x.

Abstract

1 A decrease was found in the binding capacity of elderly people for warfarin. 2 The decrease in binding correlated with a fall in plasma albumin concentrations. 3 No changes in the association constant were observed.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aging*
  • Female
  • Humans
  • Male
  • Protein Binding
  • Serum Albumin / analysis
  • Serum Albumin / metabolism*
  • Warfarin / metabolism*

Substances

  • Serum Albumin
  • Warfarin