In vivo effects of angiotensin antagonists on plasma aldosterone in the dog

Eur J Pharmacol. 1975 Dec;34(2):363-7. doi: 10.1016/0014-2999(75)90263-0.


The effects of infusions of equimolar doses of Sar1-Ile8-angiotensin II and of Sar1-Ala8-angiotensin II on plasma aldosterone, plasma renin activity and arterial blood pressure were compared in normal dogs. Plasma aldosterone increased significantly after Sar1-Ile8-angiotensin II whereas it was unaffected by Sar1-Ala8-angiotensin II. Changes in blood pressure and renin activity were small without marked differences between both groups of animals. The experiments demonstrate a clear steroidogenic potency of Sar1-Ile8-angiotensin II. Therefore, Sar1-Ala8-angiotensin II should be preferred as antagonist of the action of angiotensin II in the adrenal gland.

MeSH terms

  • Adrenal Cortex Hormones / blood
  • Aldosterone / blood*
  • Angiotensin II / analogs & derivatives
  • Angiotensin II / antagonists & inhibitors*
  • Angiotensin II / pharmacology
  • Animals
  • Blood Pressure / drug effects
  • Dogs
  • Potassium / blood
  • Renin / blood
  • Saralasin / pharmacology
  • Sodium / blood


  • Adrenal Cortex Hormones
  • Angiotensin II
  • Aldosterone
  • Sodium
  • Renin
  • Saralasin
  • Potassium